Concentration (uM)

Time (24 h)

Time (48 h)

Time (72 h)

ATO

AMN107

1

2.5

5

2.5

5

10

10.25 ± 1.38

20.38 ± 1.27

25.58 ± 1.69

30.27 ± 1.58

51.55 ± 2.72

62.74 ± 1.77

15.88 ± 1.11

24.75 ± 1.45

34.06 ± 1.20

35.34 ± 1.00

58.64 ± 1.45

67.05 ± 1.63

20.07 ± 1.46

30.59 ± 1.72

48.30 ± 2.26

45.65 ± 1.84

63.44 ± 1.70

72.07 ± 1.74

AMN107 (10) + ATO (5)

72.06 ± 2.19

81.36 ± 1.24

85.24 ± 1.36