Concentration (uM)

Time (24 h)

Time (48 h)

Time (72 h)

Control group

ATO

AMN107

0

1

2.5

5

2.5

5

10

1.39 ± 0.07

1.12 ± 0.02

1.01 ± 0.01

0.89 ± 0.00

0.84 ± 0.02

0.78 ± 0.02

0.66 ± 0.03

1.22 ± 0.03

1.06 ± 0.01

0.94 ± 0.01

0.85 ± 0.01

0.79 ± 0.02

0.72 ± 0.02

0.59 ± 0.01

1.18 ± 0.02

1.02 ± 0.01

0.91 ± 0.01

0.79 ± 0.00

0.71 ± 0.02

0.63 ± 0.01

0.51 ± 0.01

AMN107 (10) + ATO (5)

0.51 ± 0.00

0.46 ± 0.00

0.37 ± 0.02