阿昔洛韦杂质IM5和IM6的合成研究
Synthesis of Acyclovir Impurities IM5 and IM6
DOI: 10.12677/HJMCe.2024.121001, PDF,    科研立项经费支持
作者: 张钰滢, 赵洋洋, 高小萱, 杜寒莹, 黄佳雯, 周心宇, 胡婧彤, 周德军*, 赵桂琴*：承德医学院中药研究所河北省中药研究与开发重点实验室，河北 承德
关键词: 阿昔洛韦；杂质IM-5；杂质IM-6；合成；Acyclovir； Impurity-5； Impurity-6； Synthesis
摘要: 阿昔洛韦，又名无环鸟苷，是一种必不可少的抗病毒类药物，主要用于单纯疱疹病毒所致的各种感染，是治疗HSV脑炎的首选药物。本论文以阿昔洛韦的杂质IM-5和IM-6为研究对象，以乙二醇为原料，设计了一条合适的阿昔洛韦杂质IM-5和IM-6的合成工艺。
Abstract: Acyclovir, also known as acyclia guanosine, is an essential antiviral drug that is mainly used for various infections caused by herpes simplex virus and is the drug of choice for the treatment of HSV encephalitis. In this paper, the impurities IM-5 and IM-6 of acyclovir were studied, and a suitable synthetic process of IM-5 and IM-6 of acyclovir was designed using ethylene glycol as raw material.
文章引用：张钰滢, 赵洋洋, 高小萱, 杜寒莹, 黄佳雯, 周心宇, 胡婧彤, 周德军, 赵桂琴. 阿昔洛韦杂质IM5和IM6的合成研究[J]. 药物化学, 2024, 12(1): 1-8. https://doi.org/10.12677/HJMCe.2024.121001

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